Amylin (1 - 37), human

Catalog Number:
LT110006
Name:
amlintide, Amylin (1 - 37), human, amylin, Pancreatic Amylin, Islet Amyloid, islet amyloid polypeptide precursor, IAPP precursor
CAS Number:
122384-88-7
Lot Number:

LT180124-LT110006

Sequence:
KCNTATCATQ RLANFLVHSS NNFGAILSST NVGSNTY,(C-terminal amide: Tyr37; Disulfide bridge:2-7),
KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY,
H-KC(1)NTATC(1)ATQRLANFLVHSSNNFGAILSSTNVGSNTY-[NH2].

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KCNTATCVTQRLANFLLRSSNNLGAILSPT;
KCNTATCVTQRLADFLVRSSSNIGAIYS;
KCNTATCVTQRLADFLLRSSNNLGAILSPTNVGSNTY;
KCNTATCVTQRLANFLLRSSNNLGAIYSPTNVGSNTY;
KCNTATCVTQRLANFLVRSSNNLGAILSPTNVGSNTY;
KCNTATCVTQRLADFLLRSSSNIGAIYSPTNVGSNTY;
KCNTATCVTQRLADFLVRSSSNIGAILSPTNVGSNTY;
KCNTATCVTQRLADFLVRSSSNLGAIYSPTNVGSNTY;
KCNTATCVTQRLANFLLRSSNNIGAILSPTNVGSNTY;
KCNTATCATQRLANFLLRSSNNLGAILSPTNVGSNTY;
KCNTATCATQRLADFLVRSSSNIGAIYSPTNVGSNTY;
Quantity:
1mg, acetate salt, Lyophilized
Purity:
98.026% HPLC, acetate salt
Molecular Formula:
C165H265N51O55S2
Molecular Weight:

3903.26

Exact Mass:
3900.8636
IUPAC:
L-lysyl-L-cysteinyl-L-asparagyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparagyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparagyl-L-asparagyl-L-phenylalanyl-glycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparagyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-threonyl-L-tyrosinamide (2->7)-disulfide
Applications:
Amlintide, Islet Amyloid Polypeptide (IAPP) or amylin is a peptide hormone produced and stored in the beta-islet cells of the pancreas along with insulin. Amlintide forms amyloid fibrils in vitro. The deposition of fibrillar IAPP has been correlated with the pathology of type II diabetes. The helical dimerization of IAPP accelerates fibril formation and that insulin impedes fibrillation by blocking the IAPP dimerization interface.
Storage:
Store at -20°C for up to 2 years.
Images:
Amlintide Amylin Structure
Amlintide Amylin Structure
Amlintide Amylin Sequence
Amlintide Amylin Sequence
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