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Angiopep 2: TFFYGGSRGKRNNFKTEEY |
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TFFYGGSRGKRNNFKTEEY, Thr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-Tyr |
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5 mg |
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>95% |
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LT2667 |
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N/A |
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2301.46 |
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C104H150N29O31 |
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The peptide TFFYGGSRGKRNNFKTEEY is part of the angiopep family derived from the Kunitz domain of human aprotinin. The peptide can cross the blood brain barrier (BBB) and was used to facilitate the delivery of pharmacological agents to the brain. Angiopep-2 interacts with low-density lipoprotein receptor-related protein 1 (LRP1), which can promote its delivery across the BBB via receptor-mediated transcytosi . Angiopep-2 has higher transcytosis capacity and higher brain volume of distribution than aprotinin. |
