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The immunodominant myelin basic protein (MBP) peptide comprising residues 87-99 is a self-antigen in multiple sclerosis (MS). Lys(91) and Pro(96) residues are important for encephalitogenicity. Replacement of Lys and/or Pro residues with Arg and/or Ala, respectively, results in suppression of experimental allergic encephalomyelitis (EAE). The potent linear altered peptide ligand of the immunodominant sequence MBP(87-99) may lead to the design of potent antagonist mimetics for treating MS. The altered peptide ligands (APLs) has a different topology, which could provide a possible mechanism of action for T-cell receptor (TCR) antagonism. Reference 1: DOI: 10.1021/jm0102147;
Reference 2: DOI: 10.1016/j.jmgm.2007.02.004 |
