| Peptide H-2Db Adpgk Neoepitope, ASMTNMELM, NH2- Ala - Ser - Met - Thr - Asn - Met - Glu - Leu - Met -COOH
The peptide sequence ASMTNMELM belongs to the Mouse Class I family and is frequently employed in Immunology research, particularly in the context of Major Histocompatibility Complex (MHC) Multimer assays. These assays are crucial for studying the immune system's response to antigens, such as those present in infectious diseases or cancer.
Functionally, Peptide H-2Db Adpgk Neoepitope, ASMTNMELM acts as an epitope, representing a specific portion of an antigen that can be recognized by T cells when presented in the context of MHC molecules. In this case, ASMTNMELM binds to MHC Class I molecules expressed on the surface of antigen-presenting cells, such as dendritic cells or macrophages. Once bound, the MHC-peptide complex is recognized by T cell receptors (TCRs) on CD8+ T cells, triggering immune responses such as cytokine release or cytotoxic activity against cells displaying the peptide.
Applications of ASMTNMELM extend to various areas of Immunology research. It is commonly utilized in MHC Multimer assays to detect and quantify antigen-specific CD8+ T cells in biological samples. These assays are essential for studying immune responses to pathogens, monitoring vaccine efficacy, and evaluating immunotherapy treatments for diseases like cancer.
Additionally, ASMTNMELM can be employed in studies investigating antigen presentation pathways, MHC-peptide interactions, and T cell receptor recognition. By studying how this peptide interacts with MHC molecules and TCRs, researchers can gain insights into the mechanisms underlying T cell-mediated immune responses and potentially identify new targets for immunotherapy development.
ASMTNMELM serves as a valuable tool in Immunology research, enabling the study of antigen-specific CD8+ T cell responses and contributing to our understanding of immune system function and regulation. Its application in MHC Multimer assays and related experiments provides critical insights into adaptive immune responses and holds promise for the development of novel immunotherapeutic approaches. | 