Bioactive tetrapeptide GEKG boosts extracellular matrix formation. The topical application of the
matrikine GEKG to human skin stimulates ECM protein expression
of collagen at the mRNA and protein level, and of hyaluronan
and fibronectin, respectively, and that this is associated with a significant
improvement of skin physiological and clinical parameters
such as skin wrinkles and skin roughness reflecting skin ageing.
Tetrapeptides PKEK (Proline-Lysine-Glutamic Acid-Lysine) and GEKG (Glycine-Glutamic Acid-Lysine-Glycine) are synthetic peptides used in cosmetic formulations. These peptides are known for their potential benefits in skincare, particularly in anti-aging and skin repair products. Here's a brief overview of their functions:
Tetrapeptide PKEK: This peptide is often used for its anti-inflammatory and skin repairing properties. It may help in reducing skin redness, irritation, and inflammation. It's also thought to aid in the repair of damaged skin, making it potentially beneficial in products aimed at reducing blemishes, as blemishes can involve skin inflammation and damage.
Tetrapeptide GEKG: GEKG is known for its role in stimulating collagen production and aiding in skin hydration. Enhanced collagen production can lead to improved skin elasticity and firmness, reducing the appearance of fine lines and wrinkles. Its hydrating properties can also help in maintaining healthy skin barrier function, which is essential for blemish-prone skin.
In the context of a cosmetic product for blemish removal:
Repairing and Soothing Effect: Both PKEK and GEKG could contribute positively to a blemish removal product by aiding in skin repair and reducing inflammation, which are key aspects of healing blemishes.
Stimulating Collagen Production: By promoting collagen synthesis, GEKG can improve skin texture and integrity, which can be beneficial in the overall appearance of the skin.
Hydration: Maintaining skin hydration is crucial for all skin types, including blemish-prone skin. Proper hydration can prevent the overproduction of sebum that often contributes to acne and blemishes.
Formulation Considerations: When formulating a product with these peptides, it’s important to consider their compatibility with other ingredients, their stability in your formulation, and the desired concentration for effectiveness.
Regulatory Compliance: Ensure that the use of these peptides complies with regulatory guidelines for cosmetics in your region, especially if you're planning to sell the product.
Incorporating tetrapeptides like PKEK and GEKG into a cosmetic product for blemish removal could be beneficial due to their skin repairing, anti-inflammatory, and collagen-stimulating properties. However, the effectiveness of the final product will depend on the overall formulation, including the concentration of peptides and the balance with other ingredients. | 