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| Biotinylated Human CD96/TACTILE Protein (LTP10098) |
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| LTP10098 |
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| 100ug |
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$789 In stock |
| The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development. |
| Recombinant Biotinylated Human CD96/TACTILE Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Val22-Met503. |
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| CD96/TACTILE |
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| Human |
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| P40200-2 |
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| Val22-Met503 |
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| The protein has a predicted MW of 59.1 kDa. Due to glycosylation, the protein migrates to 115-140 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Anti-CD96 Antibody, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human CD96, His Tag with the EC50 of 0.46ug/ml determined by ELISA. See testing image for detail. |
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| C-His-Avi |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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