|
| Biotinylated Human LAIR1/CD305 Protein (LTP10146) |
|
| LTP10146 |
|
| 100ug |
|
|
$789 In stock |
| LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. |
| Recombinant Biotinylated Human LAIR1/CD305 Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Gln22-His163. |
|
| LAIR1/CD305 |
|
| Human |
|
| Q6GTX8-1 |
|
| Gln22-His163 |
|
| The protein has a predicted MW of 18.2 kDa. Due to glycosylation, the protein migrates to 25-35 kDa based on the Tris-Bis PAGE result. |
|
| Immobilized Biotinylated Human LAIR1, His Tag at 0.5ug/ml (100ul/Well) on streptavidin (5ug/ml) precoated plate. Dose response curve for Anti-LAIR1 Antibody, hFc Tag with the EC50 of 7.3ng/ml determined by ELISA. See testing image for detail. |
|
| C-His-Avi |
|
| Expi293 |
|
| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
|
| Less than 1EU per ug by the LAL method. |
|
| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
|
| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
| Shipped at ambient temperature. |
|
| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
|
|  |
