Biotinylated Human TRAIL R1/DR4/TNFRSF10A Protein (LTP11074)

Product Name
Biotinylated Human TRAIL R1/DR4/TNFRSF10A Protein (LTP11074)
Catalog Number
LTP11074
Quantity
100ug
Price
$789 In stock
Background
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily.The expression of apoptosis-inducing TRAIL-R1 and TRAIL-R2 and of the decoy receptors TRAIL-R3 and TRAIL-R4 was systematically studied in all developmental stages of peripheral B cells isolated from the blood and secondary lymphoid organs. Expression of TRAIL-Rs is modulated along development, with highest levels observed in germinal center B cells.
Description
Recombinant Biotinylated Human TRAIL R1/DR4/TNFRSF10A Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Pro34-Asn239.
Target
TRAIL R1/DR4/TNFRSF10A
Species
Human
Gene/Protein ID
O00220
Exact Sequence
Pro34-Asn239
Molecular Weight
The protein has a predicted MW of 24.7 kDa. Due to glycosylation, the protein migrates to 25-30 kDa based on the Tris-Bis PAGE result.
Activity
Immobilized Human TRAIL, No Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human TRAIL R1, His Tag with the EC50 of 0.31ug/ml determined by ELISA (QC Test). The affinity constant of 0.315 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Tag
C-His-Avi
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

Image
Biotinylated Human TRAIL R1/DR4/TNFRSF10A Protein (LTP11074)
  • 5 Units in Stock

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