Calcitonin C-Terminal Flanking Peptide (human) Acetate, also known as Katacalcin or C-Procalcitonin (human), is a biologically active peptide derived from the procalcitonin precursor. This peptide, with the sequence H-Asp-Met-Ser-Ser-Asp-Leu-Glu-Arg-Asp-His-Arg-Pro-His-Val-Ser-Met-Pro-Gln-Asn-Ala-Asn-OH, plays a significant role in calcium and bone metabolism and is of interest in various fields of biomedical research.
Applications in Biological Research
Calcitonin C-Terminal Flanking Peptide is a fragment of the larger prohormone procalcitonin, which is processed into active calcitonin and other peptides, including katacalcin. This peptide is particularly important in studies of calcium homeostasis and bone metabolism, as it is involved in the regulation of calcium levels in the blood by inhibiting bone resorption. Researchers use this peptide to study its effects on bone density and calcium balance, making it relevant in osteoporosis and other metabolic bone disease research.
Function and Mechanisms of Action
Katacalcin, as a component of procalcitonin, has been implicated in modulating inflammatory responses and is studied for its potential role in sepsis and other inflammatory conditions. The peptide’s activity is closely related to its interaction with calcitonin receptors, which are primarily located in the bones and kidneys. By binding to these receptors, katacalcin can influence bone resorption and calcium excretion, contributing to its regulatory role in calcium metabolism.
Significance in Drug Development
Given its regulatory functions in calcium metabolism, Katacalcin is of interest in the development of new treatments for conditions like osteoporosis, hypercalcemia, and other disorders related to calcium imbalance. Understanding how this peptide influences calcium and bone metabolism can lead to the development of targeted therapies that harness its natural inhibitory effects on bone resorption.
Molecular and Storage Information
The peptide has a molecular formula of C97H154N34O36S2 and a molecular weight of 2436.63 g/mol. It is typically stored as an acetate salt, which ensures its stability and solubility for experimental use. Proper storage conditions, such as low temperatures, are necessary to maintain its bioactivity.
Calcitonin C-Terminal Flanking Peptide (human) Acetate is thus a critical tool for researchers investigating the complex mechanisms of bone and calcium metabolism, with promising implications for drug development in the treatment of related diseases. | 