C-Peptide (human) Trifluoroacetate is a synthetic version of the human proinsulin connecting peptide, commonly referred to as C-peptide. This peptide plays a crucial role in insulin production, where it links the A and B chains of proinsulin. During insulin biosynthesis, C-peptide is enzymatically cleaved from proinsulin in the pancreas, releasing both C-peptide and insulin (composed of the A and B chains bonded together) into the bloodstream in equimolar amounts.
Applications in Research and Clinical Trials
C-peptide (human) is a highly valuable biomarker for assessing endogenous insulin secretion, making it indispensable in both clinical diagnostics and research settings. The measurement of C-peptide under standardized conditions offers a sensitive and clinically validated method for evaluating beta-cell function in the pancreas, especially in patients with type 1 diabetes. It is the primary outcome measure in clinical trials aimed at preserving or enhancing endogenous insulin production in these patients.
Influence on Physiological Conditions
Beyond its role as a biomarker, C-peptide has been shown to influence a variety of physiological conditions related to diabetes, including neuropathy, nephropathy, and encephalopathy. Clinical studies have demonstrated that C-peptide can ameliorate and even reverse the degrading effects of diabetic neuropathy, providing therapeutic potential for addressing these complications. This hormonal activity suggests that C-peptide administration may have broader applications in managing diabetes-related conditions.
Significance in Drug Development
In drug development, particularly for diabetes treatments, C-peptide serves as a crucial indicator of beta-cell function, helping to evaluate the efficacy of therapies aimed at preserving the body’s natural insulin production. Its ability to mitigate complications associated with diabetes, such as kidney and nerve dysfunctions, positions it as a promising candidate for therapeutic interventions beyond its traditional diagnostic use.
Molecular and Storage Information
The peptide has the molecular formula C129H211N35O48 and a molecular weight of 3020.30 g/mol. It is available as a trifluoroacetate salt, which enhances its solubility and stability for research applications. Proper storage at temperatures below -15°C is essential to maintain the peptide’s integrity.
This peptide is crucial for researchers focusing on diabetes, pancreatic disorders, and related fields, providing a reliable tool for both diagnostic and therapeutic research applications. | 