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| Cynomolgus Fc gamma RIII/CD16 Protein (LTP10549) |
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| LTP10549 |
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| 100ug |
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$360 In stock |
| Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn receptors has been determined.A common set of IgG1 residues is involved in binding to all Fc gamma R; Fc gamma RII and Fc gamma RIII also utilize residues outside this common set. |
| Recombinant Cynomolgus Fc gamma RIII/CD16 Protein is expressed from Expi293 with His tag at the C-terminal. It contains Gly17-Gln208. |
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| Fc gamma RIII/CD16 |
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| Cynomolgus |
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| Q8SPW2-1 |
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| Gly17-Gln208 |
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| The protein has a predicted MW of 23.1 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on the Tris-Bis PAGE result. |
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| The affinity constant of 0.251 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
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| C-His |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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