| Cynomolgus TREM2 Protein (LTP10373) |
| LTP10373 |
| 100ug |
|
$360 In stock |
| TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. |
| Recombinant Cynomolgus TREM2 Protein is expressed from Expi293 with His tag at the C-terminal. It contains His19-Ser174. |
| TREM2 |
| Cynomolgus |
| A0A2K5UY39-1 |
| His19-Ser174 |
| The protein has a predicted MW of 18.5 kDa. Due to glycosylation, the protein migrates to 33-42 kDa based on the Tris-Bis PAGE result. |
| Immobilized Cynomolgus TREM2, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-TREM2 Antibody, hFc Tag with the EC50 of 158.1ng/ml determined by ELISA. See testing image for detail. |
| C-His |
| Expi293 |
| > 95% as determined by Tris-Bis PAGE |
| Less than 1EU per ug by the LAL method. |
| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
| Shipped at ambient temperature. |
| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| ![Cynomolgus TREM2 Protein (LTP10373)](/peptide-product/images/protein-products/LTP10373/20221207151029.png) |