Exendin (9-39) corresponds to the C-terminal part of the bioactive peptides exendin-3 and -4 isolated from the venom of Heloderma suspectum. Exendin is a potent Glucagon-Like Peptide 1 (GLP-1) receptor antagonist. It has a VIP/secretin-like biological activity. It is a competitive inhibitor of Exendin-3 and Exendin-4 when binding to the exendin receptor. |