| Human ARTN Protein (LTP10460) |
| LTP10460 |
| 100ug |
|
$450 In stock |
| Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons. |
| Recombinant Human ARTN Protein is expressed from Expi293 with hFc tag at the N-terminal. It contains Ala108-Gly220. |
| ARTN |
| Human |
| Q5T4W7-1 |
| Ala108-Gly220 |
| The protein has a predicted MW of 39.3 kDa. Due to glycosylation, the protein migrates to 48-52 kDa based on the Tris-Bis PAGE result. |
| Immobilized Human GFRA3, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human ARTN, hFc Tag with the EC50 of 0.17ug/ml determined by ELISA. See testing image for detail. |
| N-hFc |
| Expi293 |
| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Less than 1EU per ug by the LAL method. |
| Lyophilized from 0.22 um filtered solution in 4mM HCl (pH 2.8). Normally 8% trehalose is added as a protectant before lyophilization. |
| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
| Shipped at ambient temperature. |
| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in 4mM HCl (pH2.8). |
| ![Human ARTN Protein (LTP10460)](/peptide-product/images/protein-products/LTP10460/20220613101609.png) |