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| Human BACE-1 Protein (LTP10618) |
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| LTP10618 |
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| 100ug |
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$327 In stock |
| The beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) initiates the generation of amyloid-? (A?), and the amyloid cascade leading to amyloid plaque deposition, neurodegeneration, and dementia in Alzheimer's disease (AD). Clinical failures of anti-A? therapies in dementia stages suggest that treatment has to start in the early, asymptomatic disease states. |
| Recombinant Human BACE-1 Protein is expressed from Expi293 with His tag at the C-terminal. It contains Thr22-Thr457. |
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| BACE-1 |
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| Human |
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| NP_036236.1 |
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| Thr22-Thr457 |
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| The protein has a predicted MW of 49.5 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on the Tris-Bis PAGE result. |
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| 0 |
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| C-His |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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