Human CD37 Protein (LTP10583)

Product Name
Human CD37 Protein (LTP10583)
Catalog Number
LTP10583
Quantity
100ug
Price
$406 In stock
Background
CD37 is a tetraspanin expressed prominently on the surface of B cells. It is an attractive molecular target exploited in the immunotherapy of B cell-derived lymphomas and leukemia. Currently, several monoclonal antibodies targeting CD37 as well as chimeric antigen receptor-based immunotherapies are being developed and investigated in clinical trials. Given the unique role of CD37 in the biology of B cells, it seems that CD37 constitutes more than a docking point for monoclonal antibodies, and targeting this molecule may provide additional benefit to relapsed or refractory patients.
Description
Recombinant Human CD37 Protein is expressed from Expi293 with hFc tag at the N-terminal. It contains Ala113-Asn240.
Target
CD37
Species
Human
Gene/Protein ID
P11049-1
Exact Sequence
Ala113-Asn240
Molecular Weight
The protein has a predicted MW of 41.9 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on the Tris-Bis PAGE result.
Activity
0
Tag
N-hFc
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

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Human CD37 Protein (LTP10583)
  • 5 Units in Stock

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