|
| Human CD38 Protein (LTP10582) |
|
| LTP10582 |
|
| 100ug |
|
|
$406 In stock |
| CD38 is highly and uniformly expressed on multiple myeloma (MM) cells, and at relatively low levels on normal lymphoid and myeloid cells, and in some tissues of nonhematopoietic origin. CD38 is a transmembrane glycoprotein with ectoenzymatic activity, and also functions as a receptor and adhesion molecule. Altogether, this has triggered the development of several CD38 antibodies including daratumumab (fully human), isatuximab (chimeric), and MOR202 (fully human). |
| Recombinant Human CD38 Protein is expressed from Expi293 with hFc tag at the C-terminal. It contains Val43-Ile300. |
|
| CD38 |
|
| Human |
|
| P28907-1 |
|
| Val43-Ile300 |
|
| The protein has a predicted MW of 56.6 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on the Tris-Bis PAGE result. |
|
| Immobilized Human CD38, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CD38 Antibody, hFc Tag with the EC50 of 17.4ng/ml determined by ELISA. See testing image for detail. |
|
| C-hFc |
|
| Expi293 |
|
| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
|
| Less than 1EU per ug by the LAL method. |
|
| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
|
| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
| Shipped at ambient temperature. |
|
| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
|
|  |
