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| Human DLL4 Protein (LTP10833) |
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| LTP10833 |
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| 100ug |
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$270 In stock |
| Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate. |
| Recombinant Human DLL4 Protein is expressed from Expi293 with His tag at the C-terminal. It contains Ser27-Pro524. |
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| DLL4 |
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| Human |
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| Q9NR61 |
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| Ser27-Pro524 |
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| The protein has a predicted MW of 55.7 kDa. Due to glycosylation, the protein migrates to 62-68 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human DLL4, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-DLL4 Antibody, hFc Tag with the EC50 of 24.1ng/ml determined by ELISA. See testing image for detail. |
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| C-His-Avi |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS, 200mM L-arginine (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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