Human FGFR3 beta (IIIc) Protein (LTP11061)

Product Name
Human FGFR3 beta (IIIc) Protein (LTP11061)
Catalog Number
LTP11061
Quantity
100ug
Price
$406 In stock
Background
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid?box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts.
Description
Recombinant Human FGFR3 beta (IIIc) Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Asp127-Gly377.
Target
FGFR3 beta (IIIc)
Species
Human
Gene/Protein ID
P22607
Exact Sequence
Asp127-Gly377
Molecular Weight
The protein has a predicted MW of 30.1 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on the Tris-Bis PAGE result.
Activity
Immobilized Human FGFR3 beta (IIIc) at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-FGFR3 Antibody, hFc Tag with the EC50 of 13ng/ml determined by ELISA. See testing image for detail.
Tag
C-His-Avi
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

Image
Human FGFR3 beta (IIIc) Protein (LTP11061)
  • 5 Units in Stock

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