Human IgG1 Fc Protein (LTP10956)

Product Name
Human IgG1 Fc Protein (LTP10956)
Catalog Number
LTP10956
Quantity
100ug
Price
$113 In stock
Background
IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (Fc?R) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues.IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.
Description
Recombinant Human IgG1 Fc is expressed from Expi293 without tag. It contains Asp103-Lys330.
Target
IgG1 Fc
Species
Human
Gene/Protein ID
P01857
Exact Sequence
Asp103-Lys330
Molecular Weight
The protein has a predicted MW of 25.5 kDa. Due to glycosylation, the protein migrates to 31-33 kDa based on the Tris-Bis PAGE result.
Activity
The affinity constant of 0.40 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Tag
No Tag
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

Image
Human IgG1 Fc Protein (LTP10956)
  • 5 Units in Stock

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