| Human Integrin alpha A1 beta 1 (ITGA1&ITGB1) Heterodimer Protein (LTP10165) |
| LTP10165 |
| 100ug |
|
$563 In stock |
| Integrin ?1?1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen?binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin ?1?1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome. |
| Recombinant Human Integrin alpha A1 beta 1 (ITGA1&ITGB1) Heterodimer Protein is expressed from Expi293 with His tag at the C-terminal. It contains Phe29-Pro1141(ITGA1)&Gln21-Asp728(ITGB1). |
| Integrin alpha A1 beta 1 (ITGA1&ITGB1) Heterodimer |
| Human |
| P56199-1(ITGA1)&P05556(ITGB1) |
| Phe29-Pro1141(ITGA1) & Gln21-Asp728(ITGB1) |
| The protein has a predicted MW of 129.1 kDa(ITGA1)&83.2 kDa(ITGB1). Due to glycosylation, the protein migrates to 160-200 kDa based on the Tris-Bis PAGE result. |
| 0 |
| C-His |
| Expi293 |
| > 95% as determined by Tris-Bis PAGE |
| Less than 1EU per ug by the LAL method. |
| Lyophilized from 0.22 um filtered solution in 50 mM Tris, 150 mM NaCl (pH 7.5). Normally 8% trehalose is added as a protectant before lyophilization. |
| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
| Shipped at ambient temperature. |
| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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