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| Human LAG3/CD223 Protein (LTP10771) |
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| LTP10771 |
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| 100ug |
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$406 In stock |
| LAG-3, is a protein which in humans is encoded by the LAG3 gene, which is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders. |
| Recombinant Human LAG3/CD223 Protein is expressed from Expi293 with hFc tag at the C-terminal. It contains Leu23-Leu450. |
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| LAG3/CD223 |
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| Human |
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| P18627-1 |
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| Leu23-Leu450 |
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| The protein has a predicted MW of 72.4 kDa. Due to glycosylation, the protein migrates to 75-80 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human FGL1, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human LAG3, hFc Tag with the EC50 of 0.16ug/ml determined by ELISA. See testing image for detail. |
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| C-hFc |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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