| Human LILRB1/CD85j/ILT2 Protein (LTP10449) |
| LTP10449 |
| 100ug |
|
$406 In stock |
| LILRB1, also known as CD85j and ILT2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family. Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs.LILRB1 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. |
| Recombinant Human LILRB1/CD85j/ILT2 Protein is expressed from Expi293 with mFc (IgG1) tag at the C-terminal. It contains Gly24-His458. |
| LILRB1/CD85j/ILT2 |
| Human |
| Q8NHL6-1 |
| Gly24-His458 |
| The protein has a predicted MW of 73.5 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on the Tris-Bis PAGE result. |
| Immobilized Human LILRB1, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-LILRB1 Antibody, hFc Tag with the EC50 of 8.0ng/ml determined by ELISA. See testing image for detail. |
| C-mFc |
| Expi293 |
| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Less than 1EU per ug by the LAL method. |
| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
| Shipped at ambient temperature. |
| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| ![Human LILRB1/CD85j/ILT2 Protein (LTP10449)](/peptide-product/images/protein-products/LTP10449/20220119181930.png) |