Human MICB Protein (LTP10917)

Product Name
Human MICB Protein (LTP10917)
Catalog Number
LTP10917
Quantity
100ug
Price
$473 In stock
Background
MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Description
Recombinant Human MICB Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Ala23-Gly298.
Target
MICB
Species
Human
Gene/Protein ID
Q29980-1
Exact Sequence
Ala23-Gly298
Molecular Weight
The protein has a predicted MW of 34.4 kDa. Due to glycosylation, the protein migrates to 48-65 kDa based on the Tris-Bis PAGE result.
Activity
Immobilized Human MICB, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-MICB Antibody, hFc Tag with the EC50 of 42.4ng/ml determined by ELISA (QC Test). The affinity constant of 83.31 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Tag
C-His-Avi
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

Image
Human MICB Protein (LTP10917)
  • 5 Units in Stock

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