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| Human NKp30/NCR3/CD337 Protein (LTP10945) |
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| LTP10945 |
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| 100ug |
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$360 In stock |
| NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. |
| Recombinant Human NKp30/NCR3/CD337 Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Leu19-Thr138. |
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| NKp30/NCR3/CD337 |
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| Human |
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| AAH52582 |
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| Leu19-Thr138 |
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| The protein has a predicted MW of 20 kDa. Due to glycosylation, the protein migrates to 26-40 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human NKp30, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-NKp30 Antibody, hFc Tag with the EC50 of 7.8ng/ml determined by ELISA (QC Test). The affinity constant of 0.292 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
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| C-His-Avi |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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