Human Oncostatin M/OSM Protein (LTP10925)

Product Name
Human Oncostatin M/OSM Protein (LTP10925)
Catalog Number
LTP10925
Quantity
100ug
Price
$563 In stock
Background
OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Description
Recombinant Human Oncostatin M/OSM Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Ala26-Arg221.
Target
OSM/Oncostatin M
Species
Human
Gene/Protein ID
P13725
Exact Sequence
Ala26-Arg221
Molecular Weight
The protein has a predicted MW of 25.1 kDa. Due to glycosylation, the protein migrates to 30-40 kDa based on the Tris-Bis PAGE result.
Activity
The affinity constant of 0.662 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Tag
C-His-Avi
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

Image
Human Oncostatin M/OSM Protein (LTP10925)
  • 5 Units in Stock

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