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| Human SEZ6 Protein (LTP10342) |
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| LTP10342 |
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| 100ug |
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$450 In stock |
| Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviors after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the beta-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. |
| Recombinant Human SEZ6 Protein is expressed from Expi293 with His tag at the C-terminal. It contains Leu20-His925. |
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| SEZ6 |
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| Human |
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| Q53EL9-1 |
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| Leu20-His925 |
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| The protein has a predicted MW of 98.9 kDa. Due to glycosylation, the protein migrates to 145-150 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human SEZ6, His Tag at 0.5ug/ml (100ul/well) on the plate. ELISA determined the dose-response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 13.2ng/ml. See the testing image for detail. |
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| C-His |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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