Human SEZ6 Protein (LTP10342)

Product Name
Human SEZ6 Protein (LTP10342)
Catalog Number
LTP10342
Quantity
100ug
Price
$450 In stock
Background
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviors after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the beta-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.
Description
Recombinant Human SEZ6 Protein is expressed from Expi293 with His tag at the C-terminal. It contains Leu20-His925.
Target
SEZ6
Species
Human
Gene/Protein ID
Q53EL9-1
Exact Sequence
Leu20-His925
Molecular Weight
The protein has a predicted MW of 98.9 kDa. Due to glycosylation, the protein migrates to 145-150 kDa based on the Tris-Bis PAGE result.
Activity
Immobilized Human SEZ6, His Tag at 0.5ug/ml (100ul/well) on the plate. ELISA determined the dose-response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 13.2ng/ml. See the testing image for detail.
Tag
C-His
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

Image
Human SEZ6 Protein (LTP10342)
COA
download pdf datasheet
  • 5 Units in Stock

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