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| Human Siglec-15/CD33L3 Protein (LTP10775) |
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| LTP10775 |
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| 100ug |
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$473 In stock |
| Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. |
| Recombinant Human Siglec-15/CD33L3 Protein is expressed from Expi293 with hFc tag at the C-terminal. It contains Lys24-Gly260. |
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| Siglec-15/CD33L3 |
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| Human |
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| Q6ZMC9-1 |
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| Lys24-Gly260 |
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| The protein has a predicted MW of 52.6 kDa. Due to glycosylation, the protein migrates to 53-60 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human Siglec-15, hFc Tag at 0.2ug/ml (100ul/Well). Dose response curve for Anti-Siglec-15 Ab., hFc Tag with the EC50 of 7.37ng/ml determined by ELISA. See testing image for detail. |
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| C-hFc |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in 20mM NaAC (pH 5.0). Normally 5% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in 20mM NaAC (pH 5.0). |
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