Human Siglec-2/CD22 Protein (LTP10751)

Product Name
Human Siglec-2/CD22 Protein (LTP10751)
Catalog Number
LTP10751
Quantity
100ug
Price
$383 In stock
Background
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.
Description
Recombinant Human Siglec-2/CD22 Protein is expressed from Expi293 with hFc tag at the C-terminal. It contains Asp20-Arg687.
Target
Siglec2/CD22
Species
Human
Gene/Protein ID
P20273-1
Exact Sequence
Asp20-Arg687
Molecular Weight
The protein has a predicted MW of 101.9 kDa. Due to glycosylation, the protein migrates to 120-130 kDa based on the Tris-Bis PAGE result.
Activity
Immobilized Human Siglec-2, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-Siglec-2 Antibody, hFc Tag with the EC50 of 46.6ng/ml determined by ELISA. See testing image for detail.
Tag
C-hFc
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

Image
Human Siglec-2/CD22 Protein (LTP10751)
  • 5 Units in Stock

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