Human TIGIT Protein (LTP10723)

Product Name
Human TIGIT Protein (LTP10723)
Catalog Number
LTP10723
Quantity
100ug
Price
$450 In stock
Background
TIGIT, also called Vstm3, Vsig9, and WUCAM, is a transmembrane protein in the CD28 family of the Ig superfamily proteins.IGIT is expressed at low levels on peripheral memory and regulatory CD4 T-cells and NK cells and is up-regulated following activation of these cells.
Description
Recombinant Human TIGIT Protein is expressed from Expi293 with hFc tag at the C-terminal. It contains Met22-Pro141.
Target
TIGIT
Species
Human
Gene/Protein ID
Q495A1-1
Exact Sequence
Met22-Pro141
Molecular Weight
The protein has a predicted MW of 39.8 kDa. Due to glycosylation, the protein migrates to 48-50 kDa based on the Tris-Bis PAGE result.
Activity
Immobilized Human CD155, mFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TIGIT, hFc Tag with the EC50 of 73.0ng/ml determined by ELISA (QC Test). The affinity constant of 1.84 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Tag
C-hFc
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by SEC-HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

Image
Human TIGIT Protein (LTP10723)
  • 5 Units in Stock

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