|
| Human TLR3 Protein (LTP10625) |
|
| LTP10625 |
|
| 100ug |
|
|
$450 In stock |
| TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3. |
| Recombinant Human TLR3 Protein is expressed from Expi293 with His tag at the C-terminal. It contains Ser23-Glu703. |
|
| TLR3 |
|
| Human |
|
| Q6PCD4 |
|
| Ser23-Glu703 |
|
| The protein has a predicted MW of 78.7 kDa. Due to glycosylation, the protein migrates to 90-115 kDa based on the Tris-Bis PAGE result. |
|
| Immobilized Human TLR3, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-TLR3 Antibody, hFc Tag with the EC50 of 4.9ng/ml determined by ELISA. See testing image for detail. |
|
| C-His |
|
| Expi293 |
|
| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
|
| Less than 1EU per ug by the LAL method. |
|
| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
|
| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
| Shipped at ambient temperature. |
|
| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
|
|  |
