The peptide sequence KLTWQELYQLKYKGI(QK) is a VEGF mimicking peptide, binds to the VEGF receptors and competes with VEGF. KLTWQELYQLKYKGI is active in gastric ulcer healing in rodents when administered either orally or systemically. KLTWQELYQLKYKGI shows the ability to induce capillary formation and organization in vitro
Functions
This peptide is involved in protein interactions and signaling pathways that can influence immune modulation. Peptides like this often serve as critical fragments in the study of epitopes—the part of an antigen molecule to which an antibody attaches itself, making it valuable in immunological studies and vaccine design.
Applications in Research and Drug Studies
- Immunology: The peptide may serve as an epitope for T-cell activation studies. Understanding its role in the immune system helps in developing peptide-based vaccines and therapeutic agents for immune diseases or cancers.
- Drug Development: Peptides like this one are being explored for their potential as vaccine components or immunomodulatory agents, which can help in creating treatments that harness the body’s immune response more effectively.
- Therapeutic Targeting: Similar peptides are used to target specific proteins in therapeutic studies, helping to design drugs that can better regulate immune responses or inhibit harmful cellular activity in diseases such as cancer.
Role in Drug Studies
KLTWQELYQLKYKGI may be investigated in preclinical models to assess its ability to induce an immune response, making it a candidate for cancer immunotherapy or vaccine formulations. Research shows that peptide-based vaccines can target tumor antigens and other pathogens by stimulating the immune system, especially T-cells, against diseases.
The versatility and specificity of such peptides ensure their growing importance in biomedical research, drug development, and therapeutic interventions.
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