| Mouse TLR3 Protein (LTP10518) |
| LTP10518 |
| 100ug |
|
$473 In stock |
| TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3. |
| Recombinant Mouse TLR3 Protein is expressed from Expi293 with His tag at the C-terminal. It contains Thr25-Leu705. |
| TLR3 |
| Mouse |
| Q99MB1 |
| Thr25-Leu705 |
| The protein has a predicted MW of 78.6 kDa. Due to glycosylation, the protein migrates to 85-110 kDa based on the Tris-Bis PAGE result. |
| 0 |
| C-His |
| Expi293 |
| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Less than 1EU per ug by the LAL method. |
| Lyophilized from 0.22 um filtered solution in PBS (pH 8.0). Normally 8% trehalose is added as a protectant before lyophilization. |
| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
| Shipped at ambient temperature. |
| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| ![Mouse TLR3 Protein (LTP10518)](/peptide-product/images/protein-products/LTP10518/20210412142739.png) |