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| Mouse WISP1 Protein (LTP10327) |
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| LTP10327 |
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| 100ug |
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$450 In stock |
| The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin ?6?1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner. |
| Recombinant Mouse WISP1 Protein is expressed from Expi293 with His tag at the C-terminal. It contains Thr23-Asn367. |
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| WISP1 |
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| Mouse |
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| O54775 |
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| Thr23-Asn367 |
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| The protein has a predicted MW of 39.4 kDa. Due to glycosylation, the protein migrates to 64-68 kDa based on the Tris-Bis PAGE result. |
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| 0 |
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| C-His |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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