Nonapeptide-1, identified by the CAS number 158563-45-2 and the sequence Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, is a synthetic peptide derived from the melanocyte-stimulating hormone (MSH). This innovative ingredient has garnered attention in the cosmetic industry for its potent skin lightening properties and ability to even out skin tone by reducing hyper-pigmentation.
Acting as a competitive antagonist of the melanocortin 1 receptor (MC1R), Nonapeptide-1 exhibits a remarkable ability to inhibit the synthesis of melanin, the pigment responsible for skin color. It achieves this by blocking the action of ?-MSH, a natural hormone that stimulates melanin production in response to UV exposure. The peptide has shown a strong affinity for MC1R, with a Ki value of 40 nM, indicating its potency in competing with ?-MSH for receptor sites on melanocytes, thereby inhibiting melanin synthesis and contributing to a lighter skin tone.
Research has demonstrated that Nonapeptide-1 can significantly reduce the intracellular levels of cAMP and melanosome dispersion induced by ?-MSH in melanocytes, effectively diminishing melanin synthesis. These actions not only lighten skin but also aid in the management of skin conditions associated with hyperpigmentation, such as melasma, age spots, and sun damage.
Beyond its primary function in skin lightening, Nonapeptide-1 has been investigated for its potential benefits in treating skin conditions and regulating steroid production in the adrenal gland. Its role in the research of skin cancer, endocrinology, and metabolic diseases further underscores its multifaceted applications.
Its utility is not limited to lightening skin but extends to improving overall skin radiance and reducing the visibility of dark spots. With recommended concentrations ranging from 0.5% to 3% in topical formulations, it is a versatile ingredient suitable for various cosmetic applications aimed at enhancing skin appearance.
Despite its promising benefits, it is crucial for users to be aware of potential side effects such as drowsiness, dizziness, hypotension, or headaches, although these are more commonly associated with systemic rather than topical use.
Nonapeptide-1 represents a significant advancement in cosmetic science, offering a targeted approach to managing hyperpigmentation and enhancing skin luminosity. Its ability to inhibit melanin synthesis, combined with a good safety profile, makes it an attractive ingredient for skincare formulations aimed at achieving a brighter, more even skin tone. | 