LifeTein is proud to offer this high-quality photocleavable linker, which has been utilized in various research applications. For instance, in the study “Multifunctional surface microrollers for targeted cargo delivery in physiological blood flow” published in Science Robotics, the linker was employed to functionalize microrollers for targeted drug delivery applications. Additionally, the linker has been used in the development of biohybrid microalgae for on-demand cargo delivery, as reported in Advanced Science. These examples highlight the versatility and effectiveness of LifeTein’s photocleavable linker in advancing innovative research.
https://www.science.org/doi/10.1126/scirobotics.aba5726?utm_source=chatgpt.com
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202001256?utm_source=chatgpt.com
Function:
This specialized linker facilitates the temporary attachment of molecules to surfaces or polymers, enabling controlled release upon exposure to UV light.
Key Features:
• Photocleavable Design: Incorporates a 2-nitrobenzyl ester moiety that cleaves under UV illumination, allowing precise control over the detachment process.
• Dual Functional Groups:
• Alkyne Group: Enables efficient click chemistry reactions for attaching various molecules.
• Succinimidyl Carbonate Group: Reacts readily with amino groups on surfaces or polymers, facilitating stable linkage formation.
Applications:
• Cell Adhesion Control: Used to reversibly conjugate anti-fouling polymers like poly(ethylene glycol) (PEG) to amino-bearing surfaces, allowing dynamic modulation of cell adhesion properties.
• Drug Delivery Systems: Serves as a mechanism to attach therapeutic agents to carriers, with subsequent UV-triggered release at targeted sites.
• Biological Research: Assists in creating dynamic substrates for cell migration studies and other biological assays requiring controlled surface modifications. | 