Rat GARP&Latent TGF Beta 1 Complex Protein (LTP10143)

Product Name
Rat GARP&Latent TGF Beta 1 Complex Protein (LTP10143)
Catalog Number
LTP10143
Quantity
100ug
Price
$676 In stock
Background
GARP&Latent TGF Beta is a complex found on surface of many types of cells. In Tregs, GARP is involved in TCR-mediated activation of Latent TGF-? and thus promoting secretion and activation of TGF-?. Integrin ?v?8 on the surface of immune cells and other cells recognizes RGD in LAP, resulting in the release of mature TGF-? from the TGF-?&GARP complex.
Description
Recombinant Rat GARP&Latent TGF Beta 1 Complex Protein is expressed from Expi293 with His tag and Avi Tag at the C-terminal. It contains Ile18-Asn628(GARP)&Leu30-Arg278(Latent TGF Beta 1).
Target
GARP&Latent TGF Beta 1 Complex
Species
Rat
Gene/Protein ID
D3ZVD5(GARP)&P17246(Latent TGF Beta)
Exact Sequence
Ile18-Asn628(GARP) & Leu30-Arg278(Latent TGF Beta 1)
Molecular Weight
The protein has a predicted MW of 69.80 kDa (GARP)&41.28 kDa (Latent TGF beta 1). Due to glycosylation, the protein migrates to 70-80 kDa (GARP)&42-48 kDa&13 kDa (Latent TGF beta 1) based on the Tris-Bis PAGE result.
Activity
0
Tag
C-His-Avi
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

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Rat GARP&Latent TGF Beta 1 Complex Protein (LTP10143)
  • 5 Units in Stock

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