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Superoxide dismutase is a metalloenzyme. It is present in all living organisms, including animals, plants, and microorganisms. SOD is categorized based on its metallicity into copper, zinc-SOD (Cu, Zn-SOD), manganese-SOD (Mn-SOD), and iron-SOD (Fe-SOD). LifeTein's recombinant Superoxide Dismutase belongs to Human Copper, Zinc-Superoxide Dismutase (rh-SOD1).
LifeTein's Superoxide Dismutase1 (SOD1) is expressed and purified from E.coli. The N terminal sequence is ATKAVCVLKG. This enzyme binds to molecules of copper and zinc to break down toxic, charged oxygen molecules called superoxide radicals. The physiological significance of SOD is that it can convert toxic superoxide free radicals into hydrogen peroxide.
Studies have shown that SOD can play a critical role in reducing internal inflammation and lessening pain associated with conditions such as arthritis. Supplement with oral preparations of pure SOD enzyme is not effective because the SOD protein is easily deactivated by acids and enzymes contained in the digestive tract. However scientists have created bioavailable forms of SOD using natural plant extracts. When delicate SOD molecules are coupled with a protective protein derived from wheat and other plants, they can be delivered intact to the intestines and absorbed into the bloodstream, thus effectively enhancing the body™s own primary defense system.
SOD is a key component in cosmetic products and has been approved by many countries because it can delay aging, regulate immune response, and blood lipid levels, and prevent damage from solar radiation. SOD is an unusually stable enzyme although its apoenzyme is very unstable. |
