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| Rhesus macaque LILRB1/CD85j/ILT2 Protein (LTP10639) |
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| LTP10639 |
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| 100ug |
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$406 In stock |
| LILRB1, also known as CD85j and ILT2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family. Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs.LILRB1 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. |
| Recombinant Rhesus macaque LILRB1/CD85j/ILT2 Protein is expressed from Expi293 with hFc tag at the C-terminal. It contains Ser17-His456. |
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| LILRB1/CD85j/ILT2 |
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| Rhesus macaque |
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| F7H3G7 |
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| Ser17-His456 |
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| The protein has a predicted MW of 74.5 kDa. Due to glycosylation, the protein migrates to 80-90 kDa based on the Tris-Bis PAGE result. |
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| The affinity constant of 51.44 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
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| C-hFc |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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