|
| Tgfb1 Rabbit mAb |
|
| LTA24829 |
|
| 100ul |
|
|
$750
In stock
|
|
| This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. Mice lacking a functional copy of this gene develop severe multifocal inflammatory disease, yolk sac defects and colon cancer. |
|
| Tgfb; Tgfb-1; TGFbeta1; TGF-beta1 |
|
| |
|
| Human |
|
| 21803 |
|
| P04202 |
|
| LSTCKTIDME LVKRKRIEAI RGQILSKLRL ASPPSQGEVP PGPLPEAVLA LYNSTRDRVA GESADPEPEP EADYYAKEVT RVLMVDRNNA IYEKTKDISH SIYMFFNTSD IREAVPEPPL LSRAELRLQR LKSSVEQHVE LYQKYSNNSW RYLGNRLLTP TDTPEWLSFD VTGVVRQWLN QGDGIQGFRF SAHCSCDSKD NKLHVEINGI SPKRRGDLGT IHDMNRPFLL LMATPLERAQ HLHSSRHRRA LDTNYCFSST EKNCCVRQLY IDFRKDLGWK WIHEPKGYHA NFCLGPCPYI WSLDTQYSKV LALYNQHNPG ASASPCCVPQ ALEPLPIVYY VGRKPKVEQL SNMIVRSCKC S |
|
| Recombinant fusion protein containing a sequence corresponding to amino acids 30-390 of mouse TGFB1 (NP_035707.1). |
|
| Rabbit |
|
| Affinity Purified Monoclonal IgG |
|
| WB, IHC-P, ELISA |
|
| Mouse, Rat |
|
| 44kDa |
|
| WB,1:1000 - 1:2000|IHC-P,1:200 - 1:400|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements. |
|
|
Reconstituted antibodies stable at -80C for 12 months, 4C for 1 week. Avoid repeated freeze-thaw cycles.
|
|
|
Shipped at ambient temperature.
|
|
|
Centrifuge tubes before opening. Dissolve the lyophilized antibodies in distilled water. 5-10% glycerol is recommended.
|
|
| .jpg )
Immunohistochemistry analysis of paraffin-embedded Rat bone marrow tissue using Tgfb1 Rabbit mAb (LTA24829) at a dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Tris-EDTA Buffer (pH 9.0) prior to IHC staining. |
