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Oligo-peptide conjugation
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Monitoring T cell–dendritic cell interactions in vivo using labeled peptides
It was found that the HIV-1 Integrase binds the Viral RNA genome and is essential during Virion Morphogenesis. The L50 Peptide: Cyclo-(-Arg-Val-Arg-Thr-Arg-Gly-LysArg-Arg-Ile-Arg-Arg-DPro-Pro-) was synthesized by LifeTein and used for the inhibition assays. The L50 is a Tat-derived peptide sequence, which selectively engages both the loop and 3-nt bulge
but not the double-stranded stem of transactivation response. The TAT-derived peptide is a well-defined cell penetration peptide.
Cell Penetration Peptides
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Monitoring T cell–dendritic cell interactions in vivo using labeled peptides
The SrtA substrates Biotin–aminohexanoic acid–LPETGS and SELPETGG were used for the interactions between immune cells ‘Labelling Immune Partnerships by SorTagging Intercellular Contacts’ (LIPSTIC). The peptide-receptor interactions enable the direct measurement of dynamic cell–cell interactions. The peptides are flexible tools for use with different receptor–ligand pairs and a range of detectable labels.
Schematic representation of the LIPSTIC approach
Peptide Biotin–aminohexanoic acid–LPETGS, SELPETGG was purchased from LifeTein.
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Short Peptide Folding
LifeTein is unveiling an expedited peptide synthesis program, promising to place peptides in its customers’ hands within 3-5 business days. The RushPep™ peptide synthesis service was designed to circumvent the existing limitations of conventional solid-phase peptide synthesis (SPPS), which involves a long coupling time and low yield. RushPep™ shortens the time needed for individual coupling, deprotection and washing steps. The proprietary methodology renders processing ten times faster than in classical synthesis while simultaneously circumventing the limitations caused by the formation of by-products or intermediates to which traditional SPPS approaches are subject.
“When designing the RushPep™ methodology, our focus was to not only to produce peptides of high quality and purity but also to offer a streamlined solution that would increase the efficiency of researchers’ protein discovery workflows,” stated Dr. Ya Chen, Head of LifeTein’s Rush Peptide Synthesis Group. “RushPep™ achieves these goals by synthesizing the peptides in 3–5 business days to accelerate research and discovery.”
Chen continued, “The reliability of RushPep™ rush peptide synthesis ensures that the peptides are finished in 3–5 business days with high-batch-to-batch reproducibility. ” Most of the crude peptides have a purity of over 80%. RushPep™ peptide service is valuable for the scientists and researchers because it allows them to finish their proteomics projects in a fast and cost-efficient manner.
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Peptides for Parkinson’s disease (PD)
ID2 peptide for inhibition of tumour growth
All peptides used in this study for Parkinson’s disease were synthesized by LifeTein. The α-synuclein is an indication in the pathogenesis of Parkinson’s disease. It was found that a molecular mimicry mechanism between HSV1 and human α-synuclein could trigger PD.
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ID2 peptide for inhibition of tumour growth
How does BIRD-2 peptide kill B-cell lymphoma?
LifeTein Launches Rush Custom Peptide Synthesis Service: Peptide Delivered in 3-5 Days
Biotinylated wild-type and modified (pT27 and T27W) ID2 peptides (amino acids 14–34) were synthesized by LifeTein. ID2 binds to the VHL ubiquitin ligase complex.This ID2 peptide could be used to inhibit tumour growth for patients with glioblastoma.
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Peptides for Parkinson’s disease (PD)
How does BIRD-2 peptide kill B-cell lymphoma?
LifeTein Launches Rush Custom Peptide Synthesis Service: Peptide Delivered in 3-5 Days
The anti-apoptotic factor Bcl-2 is over-expressed in B-cell lymphoma cells as their main survival mechanism by binding to IP3R2 on the endoplasmic reticulum (ER). In this study, a cell-penetrating version of the BIRD-2 peptide (Bcl-2/IP3R Disrupter-2 peptide with a TAT sequence) made by LifeTein was used to break up the complex formed by Bcl-2 and IP3R2 in human diffuse large B-cell lymphoma (DLBCL) cells. Ca2+ signaling-related events are suggested to be the killing mechanism of BIRD-2 peptide on DLBCL cells.
BIRD-2, a peptide that specifically disrupts the Bcl2/IP3R complex, was utilized to further verify the mitochondrial Ca2+ regulatory mechanism via the Bmal1-Bcl2/IP3R signaling pathway. It was found that BIRD-2 aggravated mitochondrial Ca2+ overload and apoptosis in vitro.
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Reference:
Inhibiting Bcl-2 via its BH4 domain in DLBCL cancers to provoke pro-apoptotic Ca2+ signaling
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Peptides for Parkinson’s disease (PD)
ID2 peptide for inhibition of tumour growth
LifeTein Launches Rush Custom Peptide Synthesis Service: Peptide Delivered in 3-5 Days
Intraspecies pheromone signaling regulated by proteases is critical for fungi procreation. The fungal aspartyl protease Bar1 was shown to have unique substrate specificity of important implications in fungal evolution. LifeTein synthesized substrate peptides of Bar1, dual-tagged with DABCYL and EDANS, from the sequence of α pheromone, the native target of Bar1. Referred as internally quenched or IQ peptides, they were used in fluorescence resonance energy transfer (FRET) assays to study the enzyme kinetics of Bar1.
mBio 6(6):e01604-15. doi:10.1128/mBio.01604-15. Evolutionary selection on barrier activity: Bar1 is an aspartyl protease with novel substrate specificity.
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Peptides for Parkinson’s disease (PD)
ID2 peptide for inhibition of tumour growth
How does BIRD-2 peptide kill B-cell lymphoma?
LifeTein Launches Rush Custom Peptide Synthesis Service: Peptide Delivered in 3-5 Days
A patent has been published that describes new methods of manipulating plant stomatal development through artificially controlling how CRSP is expressing in plant cells. The cleavage of epidermal patterning factor 2 (EPF2) by a serine protease CRSP is a key regulating mechanism in plant stomatal development. A 30-mer EPF2 peptide, dual-tagged with DABCYL and EDANS, was synthesized by LifeTein to evaluate the protease activity of synthetic CRSP in a FRET assay.
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Nanoparticles Get Help from Cell-Permeable Peptides
Predicting type 1 diabetes in children
Improving Antibody Therapy For Colorectal Cancer
A tumor-permeable peptide iRGD by LifeTein targets peritoneal carinomatosis