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SIMBATM Technology: Based on a single B cell screening technology with a shorter screen time
Strong Affinity: The rabbit monoclonal antibodies are 10-100 times higher affinity than mouse monoclonal antibodies.
High Specificity: The rabbit monoclonal antibodies have improved sensitivity for assays with lower false positive signals.
Improved Stability: The rabbit's IgGs have extra disulfide bonds for improved stability and shelf life.
Broader epitope recognition: The rabbit antibodies recognize small molecules or haptens including lipids, hormones and small drugs. The antibodies can be raised for peptides with modifications, the protein with conformational epitopes or enzyme with cleavage sites.
How is the Rabbit Monoclonal Antibody Made?
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LifeTein helped designed and synthesized a series of phosphorylated peptides. Then the peptides were used for phospho-specific antibody productions. The phospo-specific antibodies by LifeTein were confirmed to react with the epidermal growth factor receptor (EGFR). The Hung's lab showed that AGO2-Y393 phosphorylation mediates EGFR-enhanced cell survival and invasiveness under hypoxia. These findings suggest that modulation of miRNA biogenesis is important for stress response in tumour cells.
... The following peptides were chemically synthesized for antibody production in mice (Lifetein Conc.), Elisa verification (LifeteinConc.) and peptide competition assay in immunohistochemistry (IHC)... Supplementary information