Biotinylated wild-type and modified (pT27 and T27W) ID2 peptides (amino acids 14–34) were synthesized by LifeTein. ID2 binds to the VHL ubiquitin ligase complex. This ID2 peptide could be used to inhibit tumor growth in patients with glioblastoma.
Tag Archives: biotinylation
Nanoparticles Get Help from Cell-Permeable Peptides
Some cell-permeable peptides can carry cargo across the cell membrane even without any covalent links. Biotinylated peptides, including L—and D-TAT peptides made by LifeTein, were used in this study to show that two types of cell surface receptors, heparan sulfate proteoglycans, and Neuropilin-1, play critical roles in the delivery of silver-based nanoparticles into cells by cell-permeable peptides.
Nano Particles & Cell-Permeable Peptides
Science Advances 06 Nov 2015: Vol. 1, no. 10, e1500821 DOI: 10.1126/sciadv.1500821. Neuropilin-1 and heparan sulfate proteoglycans cooperate in cellular uptake of nanoparticles functionalized by cationic CPP peptides.