Custom Chemical Carbohydrate Synthesis

Carbohydrate Synthesis

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LifeTein specializes in the chemical synthesis of carbohydrate derivatives, leveraging advanced glycosylation techniques to produce complex sugar compounds. Our services cater to a broad spectrum of applications, including pharmaceuticals, biotechnology, and food industries.

Our Expertise

At LifeTein, we offer a comprehensive range of carbohydrate synthesis services, including:

Glycosylation Reactions: Utilizing advanced glycosylation methods to assemble intricate carbohydrate structures.
Protection and Deprotection: Expert handling of sugar protection and deprotection to ensure the integrity of synthetic routes.
Thioglycosides Synthesis: Specialized in the production of thioglycosides for various applications.
Multi-Step Synthesis: Capable of managing complex multi-step synthetic pathways to produce advanced sugar building blocks.

Key Technologies

Orthogonal Selective One-Pot Glycosylation: Simplifies glycan assembly by avoiding repetitive protection/deprotection steps and intermediate separations.
Reactivity-Based One-Pot Glycosylation: Sequential addition of glycosyl modules according to their reactivity for ordered glycosylation.
Preactivation-Based One-Pot Glycosylation: Rapid synthesis through repeated donor preactivation and acceptor addition.
Automated Solid-Phase Glycosylation: Enhances efficiency and purification via solid-phase carriers and automation.

Achievements

LifeTein has successfully completed over 300 projects, ranging from gram-scale to multi-kilogram quantities, involving up to 20 synthetic steps. Notable achievements include the synthesis of protected disaccharides and trisaccharides at kilogram scales. See the sample list here.

Applications

Pharmaceuticals: Development of drug carriers and therapeutic agents.
Biotechnology: Production of glycoconjugates for research and development.
Food Industry: Manufacturing of carbohydrate-based food additives.

Why Choose LifeTein?

Proven Expertise: Extensive experience in carbohydrate chemistry and synthesis.
Scalable Solutions: Capabilities to handle projects of varying scales and complexities.
Quick Start: Comprehensive inventory of key starting materials for rapid project initiation.
Cutting-Edge Technologies: Utilizing the latest advancements in glycosylation and carbohydrate synthesis.

For more information on our carbohydrate synthesis services or to discuss your project requirements, please contact info@LifeTein.com. Our dedicated team of experts is ready to assist you in achieving your research and development goals.

Reference:

Alapan et al., Sci. Robot. 5, eaba5726 (2020), 20 May 2020

...A functional o-nitrobenzyl photocleavable linker [1-(5-methoxy2-nitro-4-prop-2-ynyloxyphenyl)ethyl N-succinimidyl carbonate, LifeTein LLC, Somerset, NJ)] was conjugated to the amino end of the microrollers by NHS-amino coupling chemistry. ...

Science, 24 Jul 2020: Vol. 369, Issue 6502, pp. 423-426, DOI: 10.1126/science.abb3457

...Molecule H1 was commercially synthesized by LifeTein, LLC, following the same synthesis steps reported in 23...