Product Description |
Neprilysin, also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA), is an enzyme encoded by the MME gene in humans. Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones, including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
Neprilysin peptide: Biotin-ERIGYPDDIVSNDNKLNNEYLELNYKEDEYF
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Scientific Background | Neprilysin is a 31-residue synthetic peptide with the sequence Glu-Arg-Ile-Gly-Tyr-Pro-Asp-Asp-Ile-Val-Ser-Asn-Asp-Asn-Lys-Leu-Asn-Asn-Glu-Tyr-Leu-Glu-Leu-Asn-Tyr-Lys-Glu-Asp-Glu-Tyr-Phe. Biotin provides an affinity handle for streptavidin-based capture or detection. The sequence contains 2 Lys and 1 Arg residues, contributing cationic character; contains 5 aromatic residues that can contribute to hydrophobic or aromatic interactions. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence. |
Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
